Genetic Variations Associated With Age of Onset of Alzheimer's Disease

Several single nucleotide polymorphisms (SNPs) have been shown to be associated with development of late-onset Alzheimer’s disease (LOAD). A comparison of patients who developed early-onset LOAD to late-onset LOAD revealed that while the SNPs in genes ApoE and ApoC1 are associated with both groups, SNPs in genes CR1 and CD33 are more strongly associated with early-onset LOAD and SNPs in genes BIN1 and CLU are more strongly associated with late-onset LOAD.